Erythropoietin: a multimodal neuroprotective agent
نویسندگان
چکیده
منابع مشابه
Erythropoietin; a Novel Neuroprotective Agent for Ocular Disorders
Neuroprotection aims to prevent neuronal injury, ideally with preservation of function. Many neurological disorders, including ischemic, traumatic, or degenerative insults, share common features of destruction of neurons mediated by similar pathophysiological mechanisms including apoptosis (programmed cell death), increased release of excitotoxic amino acids, (particularly glutamate), intracell...
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An autosomal recessive juvenile-onset form of Parkinson's disease (AR-JP) is caused by loss-of-function mutations of the parkin gene, which encodes a ubiquitin-protein ligase. Three recent reports demonstrate that parkin can protect neurons from diverse cellular insults, including alpha-synuclein toxicity, proteasomal dysfunction, Pael-R accumulation, and kainate-induced excitotoxicity. These f...
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Studies show that erythropoietin, besides its critical role in hematopoiesis, provides neuroprotection in hypoxic-ischemic cerebral injury. Antiapoptotic, anti-inflammatory, angiogenetic, and neurotrophic properties of erythropoietin could increase indications, currently restricted to anemia in chronic renal failure and cancer, to hypoxic-ischemic cerebral insult. In the adult and neonatal anim...
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ژورنال
عنوان ژورنال: Experimental & Translational Stroke Medicine
سال: 2009
ISSN: 2040-7378
DOI: 10.1186/2040-7378-1-4